Study in the animal and in man.
Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R.
SourceDepartment of Medical Biophysics, Institut de Biologie, Montpellier, France.

Abstract
An experimental evaluation of citrulline malate (Stimol, CAS 54940-97-5), an anti-fatigue compound, was undertaken in man and in the animal

In order to study the pharmacological activity of the substance at hepatic and renal level. In man, the protocol involved a double-blind randomized, placebo-controlled cross-over technique.

The study in the animal was blind and placebo-controlled with two randomized parallel groups. Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates.

These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.

Activity of citrulline malate on acid-base balance... [Arzneimittelforschung. 1991] - PubMed result